Home repossessions are sixth highest in Rochdale across the UK as families are struggling to cope with rising borrowing costs and unemployment.
Five areas in the North West made up the top ten as Barking and Dagenham, London, was top with 8.44 repossession claims per 1,000 homes.
The figures were collated by Shelter using Ministry of Justice records and researchers suggest there is a strong correlation between unemployment hotspots and repossessions.
Chief executive of Shelter, Campbell Robb, said: "Most people think that repossession will never happen to them, but rising unemployment, rising living costs and high house prices mean that many people are living close to the edge already, and risk falling into a spiral of debt and repossession.
"The journey from being a homeowner to becoming homeless is frighteningly swift, with just one small thing like a wage cut, a health problem or a job loss meaning that a family can no longer meet their mortgage payments.
"When repossession happens, the impact on families is devastating – research shows people think repossession is worse than having to fight a child custody battle."
Areas affected in the North West were as follows:
2. Knowsley, North West, 7.20
5. Rossendale, North West, 6.46
6. Rochdale, North West, 6.41
7. Blackburn with Darwen, North West, 6.16
8. Burnley, North West, 6.11
England average 3.50
Borrowers have been hit by a steady rise in rates for new mortgages and conditions to be able to take out a mortgage recently, despite record low interest rates.
Lenders are battling with the increased cost of funding a mortgage amid the weak economy and the ongoing Eurozone crisis.
More than a million current mortgage borrowers saw their rates rise last month following numerous increases from lenders.
Mr Robb added: "Housing is the largest monthly cost for many homeowners, yet the affordability of housing is not getting the same government attention as the monthly costs of other essentials such as food or energy bills."
He recommended those struggling with arrears should contact their mortgage provider to avoid repossession and seek advice from bodies such as Shelter.
Housing Minister Grant Shapps said: "By tackling the record deficit we inherited we've prevented the need for rapid rises in interest rates that would have put pressure on hard-working families, meaning repossessions are at their lowest level since 2007.
"But I'm determined that help is available to those facing the real and frightening prospect of losing their home.
“That's why I've given £19million to councils so they can offer short-term loans to struggling homeowners, and over £3million to the National Homelessness Advisory Service, run by Shelter and Citizens Advice, to ensure help is on hand to families when they need it most.
"Like Shelter, I would urge anyone struggling with their mortgage to seek early help, so that repossession is always the last resort."