Premier League champions Manchester City are bookmakers’ favourites to retain their title ahead rivals United – despite their recent transfer for Robin van Persie.
Roberto Mancini’s men are 13/10 to emulate last season’s success while Sir Alex Ferguson will be hoping to better the 2/1 odds most betting retailers are offering his side – with BetVictor and Blue Square offering 9/4.
And despite the Italian manager shifting favouritism back onto his Scottish counterpart, the bookermakers have only trimmed their odds for United to claim an unprecedented 20th title.
BetVictor’s Charlie McCann said: "United have eventually got their man (Van Persie) and we trimmed them from 13/5 to 5/2 when the news came through as it had been known for some time that Old Trafford was his preferred choice, but further support forced another price cut."
Roman Abramovich’s Chelsea are worth a flutter at 11/2 as the Champions League and FA Cup winners have bolstered their squad – bringing in hot prospect Eden Hazard – in order to claim their fourth Premier League success.
With their captain’s departure, Arsenal have seen their chances slip to 14/1 while a gold rush is available if backing Liverpool and Tottenham, both are tipped to lift the trophy at 33/1.
But the 29-year-old Dutchman – who was top scorer last season with 30 goals – is the favourite to be crowned again but Coral offer a cheeky 9/1 for Van Persie to win the Golden Boot award.
Van Persie’s new partner Wayne Rooney joins City’s Sergio Aguero on 8/1, while Fernando Torres – who looked to be finding his scoring form towards the end of last season, picking up Euro 2012's Golden Boot – sits on 10/1 to score the most goals.
Carlos Tevez and Luis Suarez are at 16/1 to find the back of the net more times than anyone else while enigmatic prodigy Mario Balotelli is 20/1, even further longshots are Newcastle’s Papiss Cisse 25/1, and Darren Bent and Oliver Giroud at 28/1.
Alex Donohue of Ladbrokes said: "The money we've seen suggests Van Persie will fire United to title glory.
"Since the move was confirmed we've had a rush of bets for the Red Devils, with punters also keen to side with him for the Golden Boot."
William Hill spokesman Joe Crilly added: "It looks as though Van Persie will hit the ground running for United and he could possibly reach a similar goals tally to what he achieved last season, while at the other end of the spectrum, without his goals, Arsenal's grip on third spot may slip."