Both Manchester United and City have a strong presence in Roy Hodgson’s team selection for England’s clash against Italy on Wednesday.
Three Manchester City players – Joe Hart, James Milner and Adam Johnson – will feature on what is set to be a particularly youthful squad.
Joining them will be Manchester United midfielder Michael Carrick – his first call-up since 2010 – along with Old Trafford teammates Tom Cleverley and Ashley Young.
Meanwhile two England regulars from United, Wayne Rooney and Danny Welbeck, are both missing from the squad this time round.
Hodgson explained how useful the friendly will be in seeing how the team work together.
He said: "You don't get many chances when you've got a fairly settled squad of players to look at other potential candidates so this friendly gives me the ideal opportunity."
Milner and Hart both featured in Euro 2012 however Johnson was left out of the squad that was knocked out by Italy in penalties.
Five members of Great Britain's Olympic football team are also included.
The squad is:
Goalkeepers: Jack Butland (Birmingham City), Joe Hart (Manchester City), John Ruddy (Norwich City).
Defenders: Leighton Baines (Everton), Ryan Bertrand (Chelsea), Gary Cahill (Chelsea), Steven Caulker (Tottenham Hotspur), Phil Jagielka (Everton), Kyle Walker (Tottenham Hotspur).
Midfielders: Michael Carrick (Manchester United), Tom Cleverley (Manchester United), Frank Lampard (Chelsea), Adam Johnson (Manchester City), Jake Livermore (Tottenham Hotspur), James Milner (Manchester City), Alex Oxlade-Chamberlain (Arsenal), Jack Rodwell (Everton), Ashley Young (Manchester United).
Forwards: Andy Carroll (Liverpool), Jermain Defoe (Tottenham Hotspur), Daniel Sturridge (Chelsea), Theo Walcott (Arsenal).